Dzina:γ- aminobutyric acid()GABA）

Nambala ya CAS:56-12-2

Mafanizo ofanana: 4-Aasidi ya minobutyric; asidi ya ammonia butyric;Asidi ya Pipecolic.

1. Mphamvu ya GABA pa kudyetsa ziweto iyenera kukhala yokhazikika pakapita nthawi inayake. Kudya chakudya kumagwirizana kwambiri ndi momwe ziweto ndi nkhuku zimagwirira ntchito. Monga ntchito yovuta ya khalidwe, kudyetsa kumayendetsedwa makamaka ndi dongosolo la mitsempha. Malo okhuta (Ventromedial nucleus ya hypothalamus) ndi malo odyetsera (lateral hypothalamus area) ndi omwe amawongolera nyama.

Malo oyambira a zakudya za GABA angayambitse kudyetsa ziweto mwa kuletsa ntchito ya malo okhuta, zomwe zimapangitsa kuti ziweto zizitha kudya bwino. Kafukufuku wambiri wasonyeza kuti kubaya mlingo winawake wa GABA m'madera osiyanasiyana a ubongo wa ziweto kungathandize kwambiri kudyetsa ziweto ndipo kumadalira mlingo. Kuwonjezera GABA ku zakudya zoyambira za nkhumba zonenepetsa kungathandize kwambiri kudya nkhumba, kuwonjezera kulemera, komanso sikuchepetsa kugwiritsa ntchito mapuloteni a ziweto.

2. Zotsatira za GABA pa kugaya chakudya m'mimba ndi dongosolo la Endocrine Monga neurotransmitter kapena modulator, GABA imagwira ntchito yayikulu mu dongosolo la mitsempha la Autonomic la zamoyo zokhala ndi vertebrates.

3. Zotsatira za GABA pa kayendedwe ka m'mimba. GABA imapezeka kwambiri m'mimba, ndipo ma cell a mitsempha a GABA immunoreactive kapena ma cell a mitsempha abwino amapezeka mu dongosolo la mitsempha ndi nembanemba ya njira ya m'mimba ya zoyamwitsa, ma cell a endocrine a GABA amagawidwanso mu epithelium ya mucosa ya m'mimba. GABA imalamulira maselo a minofu yosalala ya m'mimba, ma cell a endocrine ndi ma cell omwe si a endocrine. GABA yakunja imakhala ndi mphamvu yoletsa kwambiri magawo a m'mimba omwe ali okhaokha, zomwe zimawonekera mu kuchepetsa kupumula ndi kufupika kwa ma amplitude a magawo a m'mimba omwe ali okhaokha. Njira yoletsa iyi ya GABA ikhoza kukhala kudzera mu kuletsa machitidwe a cholinergic ndi/kapena osakhala a cholinergic a m'matumbo, Kuchita popanda dongosolo la adrenergic; Ikhozanso kumangirira payokha ku GABA receptor yofanana pa maselo osalala a minofu ya m'mimba.

4. GABA imayendetsa kagayidwe ka nyama. GABA imatha kukhala ndi zotsatira zosiyanasiyana m'mimba monga mahomoni am'deralo, monga pa glands zina ndi mahomoni a endocrine. Pansi pa mikhalidwe ya in vitro, GABA imatha kuyambitsa kutulutsa kwa hormone ya kukula mwa kuyambitsa GABA receptor m'mimba. Homoni ya kukula kwa nyama imatha kulimbikitsa kupanga ma peptide ena m'chiwindi (monga IGF-1), kuwonjezera kuchuluka kwa kagayidwe ka maselo a minofu, kuwonjezera kuchuluka kwa kukula ndi kuchuluka kwa kusintha kwa chakudya cha nyama. Nthawi yomweyo, idasinthanso kugawa kwa zakudya m'thupi la nyama; Zingaganizidwe kuti mphamvu ya GABA yolimbikitsa kukula ikhoza kukhala yogwirizana ndi kayendetsedwe kake ka hormone ya kukula pokhudza ntchito ya dongosolo la mitsempha la Endocrine.