Mankhwala osiyanasiyana ophera maantibayotiki pa ulimi wa nkhuku akuletsedwa pang'onopang'ono padziko lonse lapansi chifukwa cha mavuto omwe alipo kuphatikizapo mabakiteriya ophera maantibayotiki komanso kukana maantibayotiki. Tributyrin inali njira ina yothanirana ndi maantibayotiki. Zotsatira za kafukufukuyu zasonyeza kuti tributyrin ikhoza kukonza kukula kwa nkhuku mwa kusintha zizindikiro za biochemical m'magazi ndi kapangidwe ka microflora ya nkhuku zokhala ndi nthenga zachikasu. Monga momwe tikudziwira, kafukufuku wochepa sanafufuze zotsatira za tributyrin pa microbiota ya m'matumbo komanso ubale wake ndi kukula kwa nkhuku. Izi zipereka maziko asayansi ogwiritsira ntchito tributyrin pakuweta ziweto m'nthawi ino ya pambuyo pa maantibayotiki.

Asidi ya butyric imapangidwa mkati mwa lumen ya m'mimba mwa nyama mwa kuwiritsa mabakiteriya ndi chakudya chosagayidwa ndi mapuloteni amkati. 90% ya asidi ya butyric iyi imasinthidwa ndi maselo a epithelial a cecal kapena ma colonocytes kuti apereke zotsatira zabwino zambiri pa thanzi la m'mimba.

Komabe, free butyric acid ili ndi fungo loipa ndipo ndi lovuta kuigwira. Kuphatikiza apo, free butyric acids yawonetsedwa kuti imalowa kwambiri m'mimba, zomwe zimapangitsa kuti ambiri asafike m'matumbo akulu, komwe butyric acid imagwira ntchito yake yayikulu.

Chifukwa chake, sodium salt butyrate yogulitsa yapangidwa kuti ichepetse kugwiritsidwa ntchito ndikuletsa kutulutsidwa kwa butyric acid m'mimba chapamwamba.

Koma tributyrin imakhala ndi butyric acid ndi mono-butyrin ndipo m'mimba, tributyrin imasungunuka kukhala butyric acid ndi α-mono-butyrin koma m'mimba, molekyulu yayikulu imakhala α-monobutyrin yomwe imapereka mphamvu zambiri, kukulitsa kukula kwa minofu ndikulimbikitsa kukula kwa mitsempha yamagazi kuti zakudya ziziyenda bwino.

Pali matenda angapo okhudzana ndi thanzi la matumbo a nkhuku kuphatikizapo:

• kutsegula m'mimba
• matenda a malabsorption
• matenda a coccidiosis
• matenda a necrotic enteritis

Kuwonjezera kwa tributyrin kwagwiritsidwa ntchito kwambiri polimbana ndi matenda am'mimba, ndipo pamapeto pake kumawonjezera thanzi la m'matumbo a nkhuku.

Mu nkhuku zoyamwitsa, zimatha kuyamwa bwino calcium makamaka mu nkhuku zakale zoyamwitsa komanso kukonza bwino chipolopolo cha dzira.

Mu ana a nkhumba, kusintha kwa kuyamwa mkaka ndi nthawi yofunika kwambiri chifukwa cha kupsinjika kwakukulu komwe kumachitika chifukwa chosintha kuchoka pa madzi kupita ku chakudya cholimba, kusintha malo okhala, komanso kusakanikirana ndi ziweto zatsopano.

Mu kafukufuku waposachedwa wa ana a nkhumba omwe tidachita ku Rivalea, zawonetsedwa bwino kuti kuwonjezera zakudya za Tributyrin /MT 2.5 kg pambuyo posiya kuyamwa kwa masiku 35 kunawonjezera kulemera kwa thupi ndi 5% ndipo chiŵerengero cha kusintha kwa chakudya ndi mfundo zitatu.

Tributyrin ingagwiritsidwenso ntchito mu mkaka ngati cholowa m'malo mwa mkaka wonse ndipo pang'ono imachotsa zotsatira zoyipa zomwe zolowa m'malo mwa mkaka zimakhala nazo pakukula kwa matumbo.