Guanylacetic acid, yomwe imadziwikanso kuti guanylacetic acid, ndi amino acid yofanana ndi yomwe imapangidwa kuchokera ku glycine ndi L-lysine.

Guanylacetic acid imatha kupanga creatine pogwiritsa ntchito ma enzyme ndipo ndiyo yokhayo yofunika kwambiri kuti creatine ipangidwe. Creatine imadziwika ngati chosungira mphamvu, ndipo ntchito yake yayikulu ndikupanga creatine yokhala ndi phosphorylated pogwiritsa ntchito creatine kinase.

Tengani nawo mbali paulendo wa adenosinekayendedwe ka hosphate (ATP). Pamene mphamvu ya ATP siili yokwanira, phosphocreatine imasamutsa mwachangu gulu la phosphate ku adenosine diphosphate kudzera mu creatine kinase ndikulisintha kukhala adenosine triphosphate.

 

Kugwiritsa ntchito mu nyama zolusa:

Kuwonjezera 0.12%, 0.08%, ndi 0.04% guanylacetic acid ku zakudya za nkhosa 120 zodyetsedwa ndi barn Tan zolemera pafupifupi makilogalamu 20, motsatana, kunasonyeza kuti kuwonjezera 0.12% ndi 0.08% guanylacetic acid kunawonjezera kwambiri kulemera kwa tsiku ndi tsiku, mafuta a m'mitsempha, ndi kuchuluka kwa mapuloteni, komanso kuchepetsa kwambiri kuchuluka kwa mafuta a nyama.

 

Kuwonjezera kwa 0.08%asidi wa guanylaceticKuchuluka kwa nyama yonse ndi 9.77%. Pogwiritsa ntchito njira yopangira mpweya mu vitro, zotsatira za kuwonjezera kuchuluka kosiyanasiyana kwa guanylacetic acid pa bere la ng'ombe zachikasu zidaphunziridwa. Zinapezeka kuti kuwonjezera kwa 0.4% guanylacetic acid kunawonjezera kwambiri kupanga mpweya, ndipo kuchuluka kwa ammonia nayitrogeni poyamba kunawonjezeka kenako kunachepa.

Chifukwa chake, tinganene kuti kuwonjezera guanylacetic acid ku chakudya cha tsiku ndi tsiku kungathandize kuti ng'ombe zachikasu zizikhala bwino komanso kuti zikhale bwino.

Kugwiritsa ntchito mu nkhuku:

Kuwonjezera 800 mg/kg, 1600 mg/kg, 4000 mg/kg, ndi 8000 mg/kg ya guanylacetic acid ku chakudya cha tsiku ndi tsiku cha nkhuku za nkhuku kunasonyeza kuti kuwonjezera 800-4000 mg/kg ya guanylacetic acid ku chakudya kunawonjezera kwambiri kulemera kwa nkhuku za tsiku ndi tsiku, kuchepetsa chiŵerengero cha chakudya ndi kulemera kwa nkhuku za nkhuku pa masiku 22-42. Kuwonjezera 8000 mg/kg ya guanylacetic acid kunasintha zizindikiro za biochemical m'magazi monga urea nitrogen, zizindikiro za magazi, ndi bilirubin yonse. Palibe chomwe chinakhudza zizindikiro zazikulu za ziwalo zazikulu, zomwe zikusonyeza kuti kuwonjezera 8000 mg/kg ya guanylacetic acid ku chakudya cha tsiku ndi tsiku cha nkhuku za nkhuku n'kovomerezeka.

Kuwonjezera 200 mg/kg, 400 mg/kg, 600 mg/kg, ndi 800 mg/kg ya guanylacetic acid ku chakudya cha nkhuku za nkhuku kunasonyeza kuwonjezeka kwakukulu kwa kulemera kwa tsiku ndi tsiku poyerekeza ndi gulu lolamulira. Zotsatira zabwino kwambiri zinapezeka pamene milingo yowonjezera inali 600 ndi 800 mg/kg.

Kuti aphunzire momwe guanylacetic acid imakhudzira ubwino wa umuna mwa atambala, atambala 20 a masabata 28 adasankhidwa kuti adyetse zakudya zokhala ndi 0%, 0.06%, 0.12%, ndi 0.18% guanylacetic acid. Zotsatira za kafukufukuyu zidapeza kuti kuwonjezera 0.12% guanylacetic acid muzakudya kunawonjezera kwambiri kuchuluka kwa umuna, kuchuluka kwa umuna, ndi ntchito ya umuna mwa atambala, zomwe zikusonyeza kuti kuwonjezera guanylacetic acid muzakudya kungathandize kwambiri ubwino wa umuna. Onjezani 0.0314%, 0.0628%, 0.0942%, ndi 0.1256% guanylacetic acid muzakudya za tsiku ndi tsiku za nkhuku, ndikuyika magulu awiri owongolera (gulu lowongolera 1 ndi chakudya chochokera ku zomera popanda chinthu chilichonse chowonjezera, ndipo gulu lowongolera 2 ndi chakudya chokhala ndi chakudya cha nsomba chowonjezeredwa). Magulu asanu ndi limodzi omwe ali pamwambapa a chakudya cha tsiku ndi tsiku ali ndi mphamvu ndi mchere wofanana.

Zotsatira za kafukufukuyu zikusonyeza kuti kuchuluka kwa kulemera kwa magulu anayi omwe ali ndi guanylacetic acid yowonjezera ndi gulu lolamulira lachiwiri ndi okwera kuposa a gulu lolamulira lachiwiri, Gulu lolamulira lachiwiri linali ndi zotsatira zabwino kwambiri pakulemera, kutsatiridwa ndi gulu la 0.0942% guanylacetic acid; Gulu lolamulira lachiwiri linali ndi chiŵerengero chabwino kwambiri cha zinthu ndi kulemera, kutsatiridwa ndi gulu la 0.1256% guanylacetic acid.

Kugwiritsa ntchito mu nkhuku:

Kuwonjezera 800 mg/kg, 1600 mg/kg, 4000 mg/kg, ndi 8000 mg/kg yaasidi wa guanylaceticKudyetsa nkhuku za tsiku ndi tsiku kunasonyeza kuti kuwonjezera 800-4000 mg/kg ya guanylacetic acid ku chakudya kunawonjezera kwambiri kulemera kwa nkhuku za tsiku ndi tsiku, kuchepetsa chiŵerengero cha chakudya ndi kulemera kwa nkhuku za masiku 22-42. Kuwonjezera 8000 mg/kg ya guanylacetic acid kunasintha zizindikiro za biochemical m'magazi monga urea nitrogen, zizindikiro za magazi, ndi bilirubin yonse. Palibe chomwe chinakhudza kwambiri zizindikiro zazikulu za ziwalo, zomwe zikusonyeza kuti kuwonjezera 8000 mg/kg ya guanylacetic acid ku chakudya cha nkhuku za tsiku ndi tsiku n'kovomerezeka. Kuwonjezera 200 mg/kg, 400 mg/kg, 600 mg/kg, ndi 800 mg/kg ya guanylacetic acid ku chakudya cha nkhuku za tsiku ndi tsiku kunasonyeza kuwonjezeka kwakukulu kwa kulemera kwapakati pa tsiku poyerekeza ndi gulu lolamulira. Zotsatira zabwino kwambiri zinapezeka pamene milingo yowonjezera inali 600 ndi 800 mg/kg.

Kuti aphunzire momwe guanylacetic acid imakhudzira ubwino wa umuna mwa atambala, atambala 20 a masabata 28 adasankhidwa kuti adyetse zakudya zokhala ndi 0%, 0.06%, 0.12%, ndi 0.18% guanylacetic acid. Zotsatira za kafukufukuyu zidapeza kuti kuwonjezera 0.12% guanylacetic acid muzakudya kunawonjezera kwambiri kuchuluka kwa umuna, kuchuluka kwa umuna, ndi ntchito ya umuna mwa atambala, zomwe zikusonyeza kuti kuwonjezera guanylacetic acid muzakudya kungathandize kwambiri ubwino wa umuna. Onjezani 0.0314%, 0.0628%, 0.0942%, ndi 0.1256% guanylacetic acid muzakudya za tsiku ndi tsiku za nkhuku, ndikuyika magulu awiri owongolera (gulu lowongolera 1 ndi chakudya chochokera ku zomera popanda chinthu chilichonse chowonjezera, ndipo gulu lowongolera 2 ndi chakudya chokhala ndi chakudya cha nsomba chowonjezeredwa). Magulu asanu ndi limodzi omwe ali pamwambapa a chakudya cha tsiku ndi tsiku ali ndi mphamvu ndi mchere wofanana. Zotsatira za kafukufukuyu zikusonyeza kuti kuchuluka kwa kulemera kwa magulu anayi omwe ali ndi guanylacetic acid yowonjezera ndi gulu lolamulira 2 ndi okwera kuposa a gulu lolamulira 1, Gulu lolamulira 2 linali ndi zotsatira zabwino kwambiri pakulemera, kutsatiridwa ndi 0.0942%asidi wa guanylaceticgulu; Gulu lolamulira lachiwiri linali ndi chiŵerengero chabwino kwambiri cha zinthu ndi kulemera, kutsatiridwa ndi gulu la 0.1256% la guanylacetic acid.