Njira zina zochiritsira maantibayotiki zikufunika chifukwa choletsa kugwiritsa ntchito mankhwala awa ngati zinthu zolimbikitsira kukula kwa ziweto. Tributyrin ikuwoneka kuti imagwira ntchito bwino pakukweza kukula kwa nkhumba, ngakhale kuti imagwira ntchito mosiyanasiyana.

Pakadali pano, palibe zambiri zomwe zikudziwika za momwe zimakhudzira kapangidwe ka tizilombo toyambitsa matenda m'matumbo. Mu kafukufukuyu, tidafufuza kusintha kwa tizilombo toyambitsa matenda m'matumbo mwa ana a nkhumba omwe amalandira, panthawi yoyamwitsa, 0.2% tributyrin yowonjezera ku zakudya zawo zoyambira.

Gulu la Tributyrin linali ndi mphamvu yowonjezera ya kagayidwe ka mphamvu komanso mphamvu yochepa ya kagayidwe ka chakudya m'thupi. Pomaliza, zotsatira zathu zasonyeza kuti tributyrin ikhoza kupititsa patsogolo kusintha kwa tizilombo toyambitsa matenda m'matumbo, zomwe zingathandize kukonza magwiridwe antchito a nyama pambuyo posiya kuyamwa.

Zotsatira za Tributyrin pa Kusintha kwa Mimba ya M'mimba Zokhudzana ndi Machitidwe a Ana a Nkhumba Omwe Amasiya Kuyamwa

Magawo a Zamalonda

Tributyrin (yomwe imatchedwanso Glyceryl tributyrate; Glycerol tributyrate; Glycery tributyrate; propane-1,2,3-triyl tributanoate), ndi mtundu wa ester waufupi wamafuta acid.

CAS RN: 60-01-5

Nambala ya EINECS: 200-451-5

Fomula: C15H26O6

Chiwerengero cha anthu okwana: 302.36

Maonekedwe: Ndi madzi oyera mpaka achikasu okhala ndi mafuta pang'ono komanso fungo labwino.

Kusungunuka: Kusungunuka mu ethanol, chloroform ndi ether, sikusungunuka m'madzi (0.010%).

Moyo wa Shelf: Miyezi 24

Phukusi: 25KG/ Chikwama

Kusungirako: Kutsekedwa pamalo ouma komanso opumira mpweya

Tributyrinndi triglyceride yokhala ndi mamolekyu atatu a butyrate omwe amapangidwa kukhala glycerol, omwe amawonjezera kuchuluka kwa butyrate pambuyo pa hydrolyzation ndi pancreatic lipases.

Makhalidwe a Tributyrin
Mbadwo watsopano wa butyrate-glycerol ester wa butyric acid.
Kudutsa mimba 100%.
Kupereka butyric acid m'matumbo ang'onoang'ono, sikuyenera kuphimbidwa.
Mwachibadwa amapezeka mu mkaka ndi uchi.

Kuyerekeza Pakati pa Tributyrin ndi Butyrate Salt

Theka la moyo wa butyric acid ndi mphindi 6. Butyrate ndi yovuta kufika ku minofu ndi ziwalo zina kunja kwa matumbo zomwe zimaperekedwa mu mawonekedwe a butyric acid kapena butyrate. Komabe, theka la moyo wa tributyrin ndi mphindi 40, ndipo kuchuluka kwa butyrate m'magazi kumatha kupitirira 0.1mM kwa maola 0.5-4 pomwa.

Njira ndi Makhalidwe

Wogulitsa Mphamvu

Monga momwe zimadziwikira, butyric acid ndi asidi wamafuta waufupi womwe ndi gwero lalikulu la mphamvu ya maselo a epithelial m'matumbo. Mphamvu zoposa 70% za kukula kwa maselo a epithelial m'matumbo zimaperekedwa ndi butyric acid. Komabe, tributyrin imapereka butyric acid yotulutsa m'matumbo kwambiri poyerekeza ndi zinthu zina za butyrate.

Chitetezo cha M'mimba

►Tributyrin imalimbikitsa kuchulukana ndi kusiyanitsa maselo a epithelial m'matumbo, imakonza mucosa yowonongeka, ndikukulitsa malo ozungulira kuti azitha kuyamwa michere.

►Tributyrin imalimbikitsa kuwonetsa mapuloteni olumikizana m'matumbo, imasunga kulumikizana kolimba pakati pa maselo, imaletsa ma macromolecules monga mabakiteriya ndi poizoni kulowa m'thupi, komanso imasunga ntchito yotchinga m'matumbo.

►Tributyrin imalimbikitsa kutulutsa kwa mucin (Muc) ndikulimbitsa ntchito yotchinga mankhwala m'matumbo.

Chiŵerengero cha Kupulumuka Chakwera

Tributyrin imatha kulimbikitsa kapangidwe ka hemoglobin, kukonza mphamvu yonyamula mpweya, kulimbitsa dongosolo lothandizira moyo la endogenous, ndipo ikhoza kukonza ntchito ya mitochondria ndikulimbikitsa kapangidwe ka ATP, chinthu champhamvu chomwe chimayambitsa ntchito ya moyo, kuti chiwongolere kuchuluka kwa moyo kapena nyama.

Wotsutsa-Kutupa & Wotsutsa Mabakiteriya

►Mwa kuletsa ntchito ya NF-Kb, TNF-α ndi TLR, Tributyrin ikhoza kuchepetsa kuwonongeka kwa kutupa.

►Tributyrin imalimbikitsa kufalikira kwa ma peptides a chitetezo chamthupi, omwe amatha kukana tizilombo toyambitsa matenda ndi kachilombo konse.