Chowonjezera cha chakudya: Tributyrin

Zomwe zili: 95%, 90%

Tributyrin ndi chakudya chowonjezera chomwe chingathandize kukonza thanzi la matumbo a nkhuku.

Kusiya kugwiritsa ntchito maantibayotiki monga njira zolimbikitsira kukula kwa nkhuku kwawonjezera chidwi cha njira zina zopezera zakudya, powonjezera mphamvu ya nkhuku komanso kuteteza ku matenda.

Kuchepetsa kupweteka kwa dysbacteriosis
Pofuna kuyang'anira momwe matenda a dysbacteriosis amachitikira, zakudya zowonjezera monga ma probiotics ndi ma prebiotics zikuwonjezedwa kuti zikhudze kupanga ma SCFA, makamaka butyric acid yomwe imagwira ntchito yayikulu poteteza matumbo. Butyric acid ndi SCFA yachilengedwe yomwe ili ndi zotsatira zambiri zabwino monga mphamvu yake yotsutsa kutupa, mphamvu yake yofulumizitsa kukonzanso matumbo ndikulimbikitsa kukula kwa ma villi m'matumbo. Pali njira yapadera yomwe butyric acid imagwirira ntchito kudzera mu njira yopewera matenda, yomwe ndi Host Defense Peptides (HDPs) synthesis, yomwe imadziwikanso kuti anti-microbial peptides, zomwe ndi zigawo zofunika kwambiri pa chitetezo chamthupi. Ali ndi ntchito yolimbana ndi mabakiteriya ambiri, bowa, tizilombo toyambitsa matenda, ndi mavairasi ozungulira omwe amavuta kwambiri kuti tizilombo toyambitsa matenda tipeze kukana. Defensins (AvBD9 & AvBD14) ndi Cathelicidins ndi mabanja awiri akuluakulu a HDPs (Goitsuka et al.; Lynn et al.; Ganz et al.) omwe amapezeka m'nkhuku zomwe zimakulitsidwa ndi butyric acid supplementation. Mu kafukufuku wochitidwa ndi Sunkara et. al. Kupereka butyric acid kuchokera kunja kumabweretsa kuwonjezeka kwakukulu kwa majini a HDP ndipo motero kumawonjezera mphamvu yolimbana ndi matenda mwa nkhuku. Chochititsa chidwi n'chakuti, pang'ono komanso LCFAs ndizochepa.

Ubwino wa Tributyrin pa thanzi
Tributyrin ndi chinthu chomwe chimayambitsa butyric acid chomwe chimalola mamolekyu ambiri a butyric acid kutumizidwa m'matumbo ang'onoang'ono mwachindunji chifukwa cha njira yoyezera. Motero, kuchuluka kwake kumakhala kokwera kawiri kapena katatu kuposa mankhwala opangidwa ndi zinthu wamba. Esterification imalola mamolekyu atatu a butyric acid kumangiriridwa ku glycerol yomwe ingasweke kokha ndi pancreatic lipase yamkati.
Li et al. adakhazikitsa kafukufuku wa chitetezo chamthupi kuti apeze zotsatira zabwino za tributyrin pa ma cytokines oyambitsa kutupa m'ma broilers omwe amakumana ndi LPS (lipopolysaccharide). Kugwiritsa ntchito LPS kumadziwika kuti kumayambitsa kutupa m'maphunziro ngati awa chifukwa kumayatsa zizindikiro zotupa monga IL (Interleukins). Pa masiku 22, 24, ndi 26 a kafukufukuyu, ma broilers adayesedwa ndi 500 μg/kg BW LPS kapena saline mkati mwa peritoneal. Kuonjezera tributyrin m'zakudya za 500 mg/kg kunaletsa kuwonjezeka kwa IL-1β ndi IL-6 zomwe zikutanthauza kuti kuwonjezera kwake kumatha kuchepetsa kutulutsidwa kwa ma cytokines oyambitsa kutupa motero kuchepetsa kutupa m'matumbo.

Chidule
Popeza kugwiritsa ntchito mankhwala enaake oletsa kukula kwa maantibayotiki ngati zowonjezera pazakudya, njira zatsopano zowongolera ndi kuteteza thanzi la ziweto za pafamu ziyenera kufufuzidwa. Kukhazikika kwa matumbo kumagwira ntchito yofunika kwambiri pakati pa zinthu zokwera mtengo zodyetsera ndi kukulitsa kukula kwa nkhuku. Makamaka asidi wa butyric amadziwika kuti ndi wothandiza kwambiri pa thanzi la m'mimba lomwe lakhala likugwiritsidwa ntchito kale mu chakudya cha ziweto kwa zaka zoposa 20. Tributyric imatulutsa asidi wa butyric m'matumbo ang'onoang'ono ndipo ndi yothandiza kwambiri pa thanzi la m'mimba mwa kufulumizitsa njira yokonzanso matumbo, kulimbikitsa kukula kwabwino kwa villi ndikuchepetsa machitidwe a chitetezo chamthupi m'matumbo.

Tsopano popeza maantibayotiki akuchotsedwa, butyric acid ndi chida chabwino kwambiri chothandizira makampaniwa kuchepetsa zotsatira zoyipa za dysbacteriosis zomwe zikuwonekera chifukwa cha kusinthaku.