M'zaka zaposachedwapa, "maphwando osakaniza" ambiri awonekera mumakampani osamalira khungu. Samveranso zotsatsa ndi olemba mabulogu okongola omwe amabzala udzu nthawi iliyonse yomwe akufuna, koma amaphunzira ndikumvetsetsa zosakaniza zogwira mtima za zinthu zosamalira khungu zokha, kuti asankhe zinthu zosamalira khungu zoyenera iwo.

Popeza mpikisano waukulu pakati pa makampani osamalira khungu ukukulirakulira, makampani ambiri akutsatira "zosakaniza zambiri" kuti apange "zosakaniza zothandiza". Zosakaniza zosamalira khungu zomwe zimathandizidwa ndi ukadaulo wakuda zikutchuka kwambiri, zomwe zimapangitsa kuti "gulu lalikulu la zosakaniza liziyang'ana zosakaniza, ndipo gulu lalikulu la zosakaniza liziyang'ana ukadaulo".

Samalani ndi zinthu zatsopano za makampani opanga zinthu zapakhomo ndi zakunja, ndipo pezani kuti makampani opanga zinthu zapakhomowa akufulumizitsa kukweza zinthu zopangira ndi ukadaulo, kuti zinthu zatsopano zikope ogula ambiri, ndipo ukadaulo watsopano ukhoza kutsogolera makampaniwa kulowa munjira yatsopano. Kukwera kwa gulu la sayansi ndi ukadaulo kwenikweni ndi chizindikiro cha kukhudzidwa kwamkati kwa akatswiri opanga zodzoladzola.

Lipoti la 2025 lokhudza kugwiritsa ntchito sayansi ndi ukadaulo mumakampani okongoletsa likuwonetsa kuti kuphatikiza kukongola ndi ukadaulo kukukula mozama, ndipo ukadaulo wamakono wozikidwa pa sayansi ya zamoyo upitiliza kuthandiza kafukufuku ndi chitukuko ndi kupanga zinthu zatsopano zokongoletsa. Makampani okongoletsa omwe amathandizidwa ndi sayansi ndi ukadaulo adzayambitsa kuphulika kwakukulu, ndipo kukula kwa msika kudzafika pafupifupi 1 thililiyoni yuan pofika chaka cha 2025.

 

Kafukufuku ndi chitukuko cha mankhwala opangira mankhwala a nano chakhala njira yodziwika bwino ya gulu la zamankhwala ndi mankhwala padziko lonse lapansi, ndipo kugwiritsa ntchito njira zatsopano zopangira liposomes ndi vesicles monga ukadaulo wonyamula mankhwala mu zodzoladzola zogwira ntchito kwalimbikitsidwa ndikuthandizidwa ndi boma.

Popeza khungu la munthu ndi lovuta kulowa, zakudya zimakhala zovuta kufika pakhungu lozama, zomwe zimakhudza kwambiri momwe zinthu zosamalira khungu zimagwirira ntchito. Ukadaulo wa nanocarrier unayamba monga momwe nthawi zimafunira, makamaka kuthetsa mavuto okhudzana ndi kuperekedwa kwa mankhwala, kutulutsidwa pang'onopang'ono kwa mankhwala, kuyamwa kwa transdermal ndi zina zotero. Ma nanocarrier omwe amagwiritsidwa ntchito kwambiri ndi monga liposomes, hydrogel carriers, micelles, microcapsules, liquid crystal systems, supramolecules, ndi zina zotero.

Kugwiritsa ntchito zida zonyamula zinthu zazing'ono kuti zipereke zosakaniza zosamalira khungu m'malo omwe akusamalidwa ndi khungu komanso m'maselo kudzera mu kutumiza khungu, kumasula pang'onopang'ono komanso kwanthawi yayitali, kuthetsa vuto laukadaulo lomwe limapezeka m'makampani ambiri la zodzoladzola zachikhalidwe zomwe zimakhala zovuta kuyamwa kudzera pakhungu. Zida zonyamula zinthu zazing'ono zilinso ndi ntchito yokonza kusungunuka ndi kufalikira kwa madzi kwa zosakaniza zogwira ntchito za zodzoladzola zosasungunuka, kukonza kukhazikika kwa zosakaniza zogwira ntchito zomwe zimakhudzidwa ndi kuwala komanso kutentha, komanso kukonza kugwirizana kwa zosakaniza zogwira ntchito.

Kale mu 1965, akatswiri a ku Britain Bangham ndi Standish adapeza kuti ma phospholipid amatha kupanga ma vesicles a bilayer (micelle) m'madzi kudzera mu maikulosikopu yamagetsi, ndipo adawatcha kuti liposomes. Ichi chidakhala chimodzi mwa zinthu zazikulu zomwe zidapezeka m'munda wa mankhwala m'zaka za m'ma 1900.

Ngale pamwamba pa nanocarriers -- liposomes

Popeza kapangidwe koyambira ka nembanemba ya plasma yachilengedwe ndi nembanemba ya phospholipid bilayer, ma liposome ali ndi kapangidwe kofanana ndi maselo achilengedwe, kotero ali ndi biocompatibility yabwino, kotero amatchedwanso "artificial biofilm". Ma liposome amagwiritsa ntchito mgwirizano uwu kuti akwaniritse kupereka mankhwala moyenera kapena moyenera. Ma liposome abwino ayenera kukhala ndi histocompatibility yabwino, poizoni wotsika, kuyika mankhwala oyenera komanso mphamvu yotulutsa.

Monga momwe dzinalo likusonyezera, gawo lalikulu la ma liposome ndi "lipids". Ma liposome ofala kwambiri nthawi zambiri amapangidwa ndi ma phospholipid ndi cholesterol, zomwe ndi zinthu zachilengedwe zomwe zimapezeka m'zamoyo, zimagwirizana bwino ndi minofu ndipo sizimayambitsa chitetezo chamthupi.

Ndondomeko yopangira zinthu zopangira ma liposomes

Dzina la malonda la zinthu zopangira: chitetezo ku liposome yokalamba

Ndondomeko yolumikizirana pamodzi: liposome + retinol + astaxanthin + coenzyme Q10

Mphamvu ya zinthu zopangira: yaying'ono komanso yolimba makwinya

Kugwiritsa ntchito koyenera: 5% - 10%

Zogwiritsidwa ntchito: Madzi a Essence, Essence, Facial mask, Gel, Lotion, Cream