Zotsatira zapotaziyamu dicarboxylatepa thanzi la matumbo a ana a nkhumba

1) Kutsekeka kwa mabakiteriya ndi kutsekereza

Zotsatira za mayeso a in vitro zinasonyeza kuti pamene pH inali 3 ndi 4,potaziyamu dicarboxylateZingathe kuletsa kwambiri kukula kwa mabakiteriya a Escherichia coli ndi lactic acid, koma pamene pH = 5, potaziyamu dicarboxylate sinakhudze mabakiteriya a lactic acid ndipo kuchuluka kwa Escherichia coli komwe kumapulumuka kunachepa. Potaziyamu dicarboxylate inali ndi zotsatira zoletsa pa Salmonella c19-2, c19-12-77, nkhumba Escherichia coli el ndi Staphylococcus aureus.

Pamene 0.6% ndi 1.2% potassium dicarboxylate zinawonjezeredwa ku zakudya za ana a nkhumba omwe asiya kuyamwa, chiwerengero cha Escherichia coli mu duodenum, jejunum, colon ndi rectum chinachepa [94]. Kuwonjezera 0.6% potassium dicarboxylate kungachepetse chiwerengero cha Salmonella m'zakudya ndi ndowe, ndikuchepetsa kufalikira kwa Salmonella ndi Escherichia coli m'mafamu a nkhumba. Pamene 1.8% potassium dicarboxylate inawonjezeredwa ku zakudya za ana a nkhumba omwe asiya kuyamwa, chiwerengero cha Escherichia coli m'mimba ndi m'matumbo ang'onoang'ono chinachepa ndi 19.57% ndi 5.26%.

2) Kuchepetsa pH ya m'mimba

Potaziyamu dicarboxylateKungachepetse pH ya m'mimba ndi duodenal. Kuonjezera 0.9% ya potaziyamu diacid mu zakudya za ana a nkhumba olekanitsidwa kungachepetse pH ya m'mimba (5.27 mpaka 4.92), koma sikukhudza pH ya colonic chyme. Kuonjezera 0.6% kapena 1.2% ya potaziyamu dicarboxylate mu zakudya za ana a nkhumba olekanitsidwa a masiku 28 kunachepetsa pH ya m'mimba (kuchokera pa 4.4 mpaka 3.4), koma sikunakhudze pH ya duodenum, jejunum, ileum, cecum, colon ndi rectum. 0.9% ndi 1.8% ya potaziyamu dicarboxylate zinawonjezeredwa ku zakudya zoyambira za ana a nkhumba. Pambuyo powapatsa chakudya kwa mphindi 65, kuwonjezera potassium dicarboxylate kunachepetsa kwambiri pH ya duodenal, 0.32 ndi 0.40 mu gulu la 0.9% ndi gulu la 1.8%, motsatana. Potaziyamu dicarboxylate imatha kuchepetsa pH ya m'mimba, kulimbikitsa kutulutsa kwa pepsin ndikuwongolera kugaya ndi kuyamwa kwa mapuloteni.

3) Kulimbikitsa umphumphu wa matumbo

Zotsatira za 1%, 1.5% ndi 2% potaziyamu dicarboxylate pa kapangidwe ka matumbo a ana a nkhumba olekanitsidwa zinaphunziridwa. Zotsatira zake zinasonyeza kuti kutalika kwa ubweya wa pepala wa m'matumbo a ana a nkhumba wowonjezeredwa ndi 1.5% ndi 2% potaziyamu dicarboxylate kunali kwakukulu kwambiri kuposa kwa gulu lolamulira lopanda potaziyamu dicarboxylate (0.78mm mu gulu lolamulira, 0.98mm mu gulu la 1.5% potaziyamu dicarboxylate ndi 0.90min mu gulu la 2.0% potaziyamu dicarboxylate). Komabe, kuwonjezera kwa magawo osiyanasiyana a potaziyamu dicarboxylate sikunawongolere kwambiri kutalika kwa jejunum ndi ileum m'matumbo.

 

Zotsatira za potaziyamu dicarboxylate pa ntchito yaAna a Nkhumba Omwe Anasiya Kuyamwa

1) Limbikitsani kuyamwa kwa mchere

Zotsatira zake zikusonyeza kuti potaziyamu dicarboxylate imatha kulimbikitsa kuyamwa kwa mchere ndikuwonjezera kuchuluka kwa kuyamwa kwa phosphorous, magnesium, zinc, mkuwa ndi manganese ndi 8% - 9%, 3% - 8%, 9% - 17%, 52% - 60% ndi 6% motsatana. Kuyesera komaliza nkhumba kunawonetsa kuti kuwonjezera 1% ya potaziyamu dicarboxylate kungapangitse kuti mapuloteni osakonzedwa bwino azigayidwa ndi 4.34% komanso kuchuluka kwa phosphorous komwe phosphorous imagwiritsidwa ntchito ndi 1.75%. Potaziyamu dicarboxylate imatha kulimbikitsa kuyamwa kwa michere ndikulamulira mapangidwe a zinthu zovulaza. Kuwonjezera 0.9% ndi 1.8% ya potaziyamu dicarboxylate ku chakudya cha ana a nkhumba kungachepetse kuchuluka kwa ammonia m'mimba, ndipo zotsatira za 0.9% ya potaziyamu dicarboxylate ndizofunikira kwambiri.

2) Sinthani kusintha kwa chakudya

Kuwonjezera 1.8% ya potaziyamu dicarboxylate pa zakudya za ana a nkhumba olemera makilogalamu 9-21 kungapangitse kuti kukula kwa ana a nkhumba kukhale 32.7% komanso kuti chakudya chikhale chosinthika cha 12.2%, zomwe zikufanana ndi 40ppm telosin phosphate. Pamene 1.8% ya dicarboxylic acid inawonjezeredwa ku zakudya za ana a nkhumba olekanitsidwa omwe ali ndi kulemera kwa thupi kwa 7kg ndipo mphamvu ya kagayidwe kachakudya inali 13mj / kg kapena 14mj / kg, potaziyamu dicarboxylate ikhoza kuwonjezera kulemera kwa ana a nkhumba ndi 5% ndi 12% motsatana; Kuwonjezeka kwa tsiku ndi tsiku kunawonjezeka ndi 8% ndi 18% motsatana; Kuchuluka kwa chakudya kunawonjezeka ndi 6%; Kudya chakudya cha tsiku ndi tsiku kunawonjezeka ndi 1% ndi 8% motsatana.

Zotsatira zake zasonyeza kutipotaziyamu dicarboxylatekungathandize kuchepetsa kupsinjika kwa kuyamwa, kukulitsa kukula ndi kukhazikika kwa matumbo a ana a nkhumba.